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Promising anti-obesity pill







Promising anti-obesity pill

Promising anti-obesity pill 04/09/2004 04:04 PM

Rimonabant is a drug from a French pharma outfit whose clinical trials show remarkable results in controlling appetite with minimal side-effects. It's being hailed as a drug with the potential to practically address the obesity epidemic.

Dr. Despres led a trial of rimonabant in 1,036 overweight patients at high risk for heart problems. All patients were told to cut their food intake by 600 calories daily. Those who received a 20-mg dose lost an average of 20 pounds and trimmed their waistlines by three inches in one year. Those given placebos lost an average of five pounds.
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Promising anti-obesity pill

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The obesity racket || kuro5hin.org 05/02/2004 03:10 AM
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David Pescovitz: A new study from the Fred Hutchinson Cancer Research Center reports that women on birth control pills who are categorized by their body-mass index as overweight or obese are 60 to 70 percent more likely to get pregnant than "normal" weight women who also take the pill.
One possible explanation is increased metabolism. "The more a person weighs, the higher their basal metabolic rate, which can shorten the duration of a medication's effectiveness," she said. Another possibility is that the heavier a person is, the more liver enzymes they have to clear medications from the body, causing a drop in circulating blood levels of the drug. A third theory is based on the fact that the active ingredients in oral contraceptives – the hormones estrogen and progesterone – are stored in body fat. "The more fat a person has, the more likely the drug is sequestered, or trapped, in the fat instead of circulating in the bloodstream," (epidemiologist Victoria) Holt said.
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