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Avoiding Biotech Landmines







Avoiding Biotech Landmines

Avoiding Biotech Landmines 05/13/2004 10:57 AM

How to avoid high-risk biotech stocks.




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Avoiding Biotech Landmines

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AVOIDING THE
LANDMINES IN ENTREPRENEURIAL
BUSINESS


AVOIDING THE
LANDMINES IN ENTREPRENEURIAL
BUSINESS
05/04/2004 09:08 PM
stepping stones
Diagram ©2004 The Caring Enterprise Coach
Today, the average North American entrepreneurial business lasts just four years, the average sole proprietorship even less. Yet entrepreneurship is not rocket science; it's nothing more (or less) than making a living for yourself with your business partners, instead of depending on some indifferent corporation to provide you with a living wage. Running a business is certainly no more difficult than raising a family, or landing a job and building a career with a big company. The essentials of entrepreneurship could easily be taught in every school, and there'd still be plenty of time left for the rest of the school curriculum. But, perhaps because big corporations and the governments they control want the 'labour force' to be meek, subservient, fearful and insecure, most people have come to perceive entrepreneurship as a complex and difficult art, fraught with danger, unprofitable, emotionally scarring, and demanding of enormous courage and energy. "It's certainly not for everyone", I keep hearing.

Entrepreneurship requires self-knowledge of what you're happy doing, what you're especially good at, how much you're willing to put into your enterprise and what you expect to get out of it. Without this self-knowledge, you're likely to be as miserable in your own business as working for some unappreciative boss, and that unhappiness will bear directly on its success. Beyond that, all you need are common sense, self-confidence, and a modicum of four key, learnable skills:
  • creativity (the ability to discover and apply new ideas),
  • communication (written and oral),
  • information processing (the ability to distil, analyze and interpret it), and
  • interpersonal (listening, appreciation, connecting, persuading).
Then it's simply a matter of learning and following the process that every entrepreneur has learned by trial and error,  to set up and operate your own business successfully, on your own terms, and actually have fun doing it.

One of the 15 steps in the process of establishing and running an enterprise is avoiding the landmines. In MBA school they now call this Risk Management. This article identifies ten of the major landmines for entrepreneurs, using some real-life examples. I don't believe any of the enterprises described below is still in business (though some of the entrepreneurs have moved on, learned their lesson, and succeeded in other businesses):
  1. Copycat businesses: Thirty years ago I did some financial consulting for a small start-up cruise ship operation. They acquired and completely renovated a ship, which was lovely, got the licenses, hired the appropriate staff, set up the business systems, and then waited for the customers to roll in. After all, the competing operations on the same run were all fully booked. But this operation was an unknown quantity, and before they realized that just being similar to a successful and busy business wasn't enough to succeed, they sailed off into the sunset, empty. Franchisees beware.
  2. Over-estimating the market: Consultants love to sell you spreadsheets that will 'forecast' your income and cash flow. An inventor friend of mine used one of these to persuade himself to produce and sell a new organic nutritional supplement he had developed. His research showed that the annual sales of this type of product North America-wide was $X billion. The spreadsheet encouraged him to plug this number in, along with his estimate of what share of this market he could capture over three years. Needless to say, he never sold anywhere close to this amount of product, because that's not how you go about forecasting sales.
  3. Being too far ahead of or behind the market: A client of mine bought the North American rights to a new technology that would extrude a rugged, colour-fast plastic that could be used in decking, fencing, and other outdoor applications. He spent a fortune setting up the manufacturing plant. Problem is, he did this in the 1980s, when plastics were distrusted as 'cheap', wood was cheap, and creosote in pressure-treated lumber was not yet known to be a carcinogen. Being 10-15 years ahead of the market cost him his life savings.
  4. Biting off too much: A company that I was brought in to help liquidate had been doubling its sales and employee headcount every nine months. They were providing turnkey computer networking equipment and installations to mid-size companies, and had recently moved upscale to large corporations, school boards and government departments. As its receivables and inventories soared, it started paying more money for qualified talent, and its suppliers and bank both put it on short leash. Finally, despite record monthly sales, it simply ran out of cash. The owner turned down two very opportunistic 'investors', who wanted control of the business in return for working capital, and the bank pulled the plug.
  5. Not listening to the customer, or offering a solution in search of a problem: A lot of entrepreneurs are inventors, scientists, artists, artisans, administrators, teachers or managers. Sales is not their forte, and they're more comfortable working with ideas, materials, plans or systems than with those pesky people called customers. If you're not at home spending a lot of face time with customers, better partner with someone who is. If you want to see what happens if you don't, just browse any of the free software sites on the Web and see how many downloads most of them have. Some of them are quite intriguing, but because they don't meet a customer need, they'll never be more than that. Great prescription for a hobby, deadly for a business.
  6. Not consulting with or listening to the right advisors: A client of our firm in the early 1990s, a company which had been in the commercial printing business for 80 years, brought us in for some technology and corporate finance consulting. As we learned about the business it became obvious, first, that they could not afford the new equipment they proposed to buy, and secondly, that their profit margins were going through the floor. They had built their reputation on high quality printing work, but the market was no longer willing to pay for it. The new equipment would allow them to automate and eliminate some labour costs (and keep up with newer competitors with no sunk costs), but the cost of the new equipment would exceed the savings. We advised the company they needed to find some new markets, new higher-margin products, and new customers who would pay more for their quality work, or else drastically cut costs. They were convinced their customers would stay loyal, and the market for quality printing would rebound. They didn't, and the company shut its doors two years later.
  7. Blowing the budget: As most women will tell you (but many men seem unable to fathom), budgeting is simply a matter of ensuring that the cash going out doesn't exceed the cash coming in. The problem is, every start up costs more -- sometimes two or three times more -- than initially expected. It takes enormous self-discipline, patience, pacing, and sometimes financial creativity, to mete out dollars at a rate that will ensure there is enough cash to launch the business under the worst case scenario. I know of a dozen businesses that closed before they opened because they failed to do so, and others that lost control of their business unwillingly because that was the price for a late cash infusion. 'Risk Capital' might be more accurately called 'Heartbreak Capital' -- it is obscenely expensive.
  8. Groupthink: Back in the 1970s I was appointed Deputy Receiver for a computer and peripherals distributor. They had been put on 'close watch' by the bank, and I had to get authorization for, and sign, every cheque. While I was there I attended and took notes at management meetings. I was assailed at each meeting when I presented my factual reports on profit and cash flow. I was nicknamed The Undertaker for my 'relentless pessimism', and almost physically ejected when I questioned the validity of some unsupported fees that had been paid by the much-loved CFO, who was on leave of absence looking after a very sick relative. The six-man management team, intact since the start of the company and each heavily personally invested in the company, used to come out of their meetings with cheers and high fives, confident, contrary to all logic, that the company was poised for turnaround and sales 'in the pipeline' would soon bring a return to happy days. They would feed off each others' boundless optimism. They just needed to work harder. Happier days never came, and the CFO, it turns out, had defrauded the company to pay for his relative's substantial medical bills.
  9. Litigation: A small biotech company whose CEO I met at a conference a few years ago was bemoaning the huge cost of registering and defending patents. He said they had been forced to sell off one promising product to a competitor in order to pay their legal bills to defend their other intellectual capital. That had slowed them down to the point they now feared that another competitor would beat them to market, rendering the results of the litigation largely moot. Big companies can afford armies of expensive lawyers. For small companies, significant litigation can spell disaster. The competitive advantage of the entrepreneur is agility -- when products get mired in legal wrangles, it may be better to cut bait and move on to other ventures than to fight adversaries with much deeper pockets in court.
  10. Buying the MBA hype: Graduates of business school are taught how to be middle managers of large enterprises. Unfortunately, that knowledge often don't translate well to entrepreneurial businesses. A client of mine brought in a young, very successful MBA grad (he had his own daily spot on one of the local radio stations), who had, it appeared, no experience at all with entrepreneurial business. The company, which was modestly profitable, bought the young man's well-delivered 'grow or die' message and decided to 'go upscale'. They spent a small fortune on advertising, and set up a sales office and warehouse in another country. Unfortunately, the media in which the ads appeared were not the ones used by the company's customers, and there was not enough money to properly penetrate the foreign market. The expenses produced almost no growth and almost sank the company. They salvaged the situation, and their business, by finding an enterprising competitor in the foreign country who took over the hemorrhaging 'branch plant', and then striking a reciprocal marketing alliance with them.
Many entrepreneurs I know feel very lonely, exposed, and helpless. The big consulting firms aren't interested in them until they grow bigger or go public. The smaller firms are selling one or two specific products, and rarely have entrepreneurial skills to share. And these suppliers are expensive. The government is cheaper, but with a few notable exceptions they aren't very helpful either. As a result, many entrepreneurs have formed their own 'support groups', helping each other to avoid the landmines, and learning from each other's experiences and failures. Retired entrepreneurs are another good source of advice, and a quarterly business breakfast with a trusted entrepreneur or advisor with some experience in the trenches can be an excellent investment. These breakfasts don't need an agenda -- they're run as an informal 'interview', with the advisor asking pertinent, open-ended questions and listening and offering counsel and options and ideas. They are a critical element of what my new business, The Caring Enterprise Coach, offers.

Another technique entrepreneurs can employ to alert themselves to potential landmines is establishing an Advisory Board made up of people who have well-rounded business experience, knowledge of markets, and skills the entrepreneur and his partners lack. Such Advisory Boards are often reciprocal, offering mutual support and advice in lieu of fees. I am constantly surprised how few entrepreneurs use such 'support groups', relying instead on their own instincts, the counsel of inexperienced and costly 'professional advisors', and others (bankers, customers, franchisors, and various 'agencies') who have only a nominal, and purely financial, interest in the entrepreneur's success. Some 'support groups' and networks have been set up as money-making ventures, but these tend to be unwieldy and their members terribly needy -- ten people looking for advice and new customers for every one capable of offering useful information or counsel in return. It's best to create your own.

The problem, of course, is that most entrepreneurs are paradoxically too busy fighting fires and avoiding landmines, to be able to invest time finding and networking with support groups and other valuable advisors who can help them avoid the next round of fires and landmines. But, despite the failings of the first generation Social Networking tools, such tools hold enormous promise. Although Shoshana Zuboff coined the term The Support Economy to refer to federations of businesses working together to support their shared customers, the first true Support Economy may well be entrepreneurs supporting each other.

ABL Biotech Sets Up a 100 Crore Facility
at Marine Biotech Park


ABL Biotech Sets Up a 100 Crore Facility
at Marine Biotech Park
12/19/2004 03:16 PM
ABL Biotech is setting up a 100 crore facility to manufacture DHA and EHA at the Marine Biotech Park at Visakhapatnam. It would be the World's 2nd & India's 1st DHA, EHA facility. [PRWEB Dec 16, 2004]

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Landmines


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Landmines
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"Danish company has developed a plant
that can detect landmines"


"Danish company has developed a plant
that can detect landmines"
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Avoiding RSI


Avoiding RSI 10/29/2003 12:12 AM

I'm pretty sure I've never had RSI, but occasionally my wrists feel a little sore after spending time at the keyboard and I know enough about it to know that I really don't want it. This weekend I started using WorkRave after spotting a link to it on Meri's blog. It's a neat little application for Linux and Windows that sits in the background and reminds you to take short breaks from the keyboard every once in a while. Following the suggestion from the FAQ I have it set up to encourage a 15 second "micropause" every 10 minutes and a 5 minute proper rest break once an hour. It's too early to stay if I'll stick with it or get annoyed and turn it off, but I have to admit that I have been feeling a bit more comfortable at the keyboard. Whether that's purely a psychological effect from using it or the breaks are actually making a difference is hard to tell.


Avoiding Armageddon


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Avoiding The Microsoft Tax


Avoiding The Microsoft Tax 09/02/2004 07:21 PM
My latest acquisition is a 17" Apple Powerbook powered by the IBM G4 processor which I'll use to replace my XP laptop and an older G4 tower. In addition to a breathtakingly beautiful form factor, this machine has every feature I need, from DVD-R to Airport and Bluetooth connections. More importantly, there's no essential application I need that doesn't run on this platform. By Grady Booch, IBM (via MyAppleMenu)

Avoiding the wait


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Avoiding The iMac


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Businesses Avoiding Windows XP SP2


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Be careful when you crunch those numbers -- it's easy to screw up.

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Avoiding bad form data


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PHPComplete: Avoiding Over Engineering


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Pitfalls


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Pitfalls
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Avoiding Sibling Rivalry Among Big
Clients


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Clients
12/08/2003 02:22 PM
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On the Road, Avoiding Pitfalls at the
Pit Stops


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Pit Stops
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FAQ | Installing hardware, avoiding
static


FAQ | Installing hardware, avoiding
static
02/15/2004 07:05 AM
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librarian.net : avoiding the PATRIOT Act
since 2001


librarian.net : avoiding the PATRIOT Act
since 2001
09/18/2004 10:51 PM
signs to display in your local library .. avoiding the PATRIOT Act since 2001 .. Well I don't feel secure .. FBI might be monitoring .. Or can you? .. ways around

librarian.net/technicality.html
track this site | 3 links


Websites for avoiding ailments on the
road


Websites for avoiding ailments on the
road
08/02/2004 06:10 AM
Miami.com - Mon Aug 2, 08:40 am GMT

Octopuses Observed Avoiding Predators
(AP)


Octopuses Observed Avoiding Predators
(AP)
03/24/2005 07:51 PM
AP - Octopuses, known for using camouflage to avoid predators, have been observed apparently trying to sneak away by walking on two arms while pretending to be a bunch of algae. Two kinds of octopus were seen to use different ways of walking along the sea floor, researchers were reporting in Friday's issue of the journal Science.

Management: Avoiding Turf Wars


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Sony: We're open to avoiding a DVD
format war


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format war
04/16/2005 11:20 PM
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Survey Shows Admins Avoiding SP2


Survey Shows Admins Avoiding SP2 04/15/2005 05:05 AM

Sony Says Open to Avoiding DVD Format
War


Sony Says Open to Avoiding DVD Format
War
04/13/2005 11:14 AM
Sony Corp said on Wednesday it was open to discussions to create a single standard for the next generation of DVD discs, a move which could head off the looming threat of a major format war among the world's biggest technology companies. "From the point of view to provide the best service to the consumer one format is better than two. We're open to discussions," Yukinori Kawauchi, general manager in charge of the next DVD format at Sony's Video Group, said in an interview.

But he added that specific proposals had yet to be tabled. "There's no visible progress to do that (create a single standard)," Kawauchi told Reuters at an event organized by Sony. The electronics industry is facing a battle between the so-called Blu-ray optical discs and HD DVD discs, two different new DVD formats which offer higher capacity than current DVDs.

News source: Reuters

Read full story...

Congressman Urges Avoiding Times Square


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Kerry Says Bush Avoiding Reality on Iraq
(AP)


Kerry Says Bush Avoiding Reality on Iraq
(AP)
09/23/2004 02:23 AM
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Avoiding a Shocking Experience for the
Information Consumer


Avoiding a Shocking Experience for the
Information Consumer
01/23/2004 02:21 PM
Avoiding a Shocking Experience for the Information Consumer
h ttp://www.oclc.org/membership/escan/introduction/default.htm

The 2003 OCLC Environmental Scan suggests that, paradoxically, a worthy goal of the library might be "invisibility" -- in the sense that the service is ubiquitous and fully integrated into the infosphere. "After all, technology and services are most welcome in our lives when we do not have to devote much thought to them. We press a switch and light comes or goes. Expecting the information consumer to pay attention to the differences between William Shakespeare the author and William Shakespeare the subject as search terms is akin to expecting Joe Householder to know if the red wire or the black wire should be grounded before he plugs the lamp in -- and expect Joe to go to RedWire.com to figure out what happens if he's wrong. Thankfully, clever people have hidden all this technology inside a box and millions are saved from a shocking experience."

Sudan Seeks Arab Help in Avoiding
Sanctions


Sudan Seeks Arab Help in Avoiding
Sanctions
08/08/2004 10:45 AM
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Police advise on avoiding online fraud


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vnunet.com Oct 31 2003 9:24AM ET

Tips from A List Apart: Avoiding Scope
Creep


Tips from A List Apart: Avoiding Scope
Creep
09/24/2002 08:11 AM

Sony Says Open to Avoiding DVD Format
War (Reuters)


Sony Says Open to Avoiding DVD Format
War (Reuters)
04/13/2005 11:23 AM
Reuters - Sony Corp said on Wednesday it was open to discussions to create a single standard for the next generation of DVD discs, a move which could head off the looming threat of a major format war among the world's biggest technology companies.

W3C XML Schema Design Patterns: Avoiding
Complexity


W3C XML Schema Design Patterns: Avoiding
Complexity
11/20/2002 07:48 PM
Previous attempts to define an effective subset of W3C XML Schema have thrown the baby out with the bathwater, says Dare Obasanjo, who proposes a less conservative set of guidelines for working with W3C XML Schema.

MOM Admin: Avoiding MOM alerts when you
reboot DCAM servers


MOM Admin: Avoiding MOM alerts when you
reboot DCAM servers
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Unlucky Hong Kong Exec Avoiding Ceremony
(AP)


Unlucky Hong Kong Exec Avoiding Ceremony
(AP)
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AP - After a year of SARS, recession, and political turmoil, Hong Kongers may be relieved to hear Home Affairs Secretary Patrick Ho is bowing out of a Lunar New Year ceremony to predict the territory's fortunes.

After avoiding further appeals, 'DVD
Jon' slays another dragon


After avoiding further appeals, 'DVD
Jon' slays another dragon
01/06/2004 02:09 AM
After prosecutors decide against any more DeCSS appeals, Jon Johansen cracks iTMS DRM protections.

Kerry Criticizes Cheney for Avoiding
Vietnam War (Reuters)


Kerry Criticizes Cheney for Avoiding
Vietnam War (Reuters)
09/02/2004 08:55 PM
Reuters - Democrat John Kerry hit back at Dick Cheney on Thursday by raising the Republican's failure to serve in the Vietnam War and asking voters to weigh his two tours of duty against the vice president's five deferments.

"MSNBC - Avoiding attacking suspected
terrorist mastermind"


"MSNBC - Avoiding attacking suspected
terrorist mastermind"
03/06/2004 02:05 AM

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